Peripherally inserted central venous catheter in upper extremities leads to an increase in D-dimer and deep vein thrombosis in lower extremities

Abstract Background The purpose of this study is to elucidate the association between peripherally inserted central venous catheter (PICC) in upper extremities and lower extremity deep thrombosis (LEDVT) by observing changes D-dimer. Methods This was a retrospective cohort with 3452 patients (104 PICCs 3348 without PICC) enrolled at neurology department from April 1, 2017 2020. underwent color Doppler ultrasound (CDU) D-dimer examinations. LEDVT-related factors value were analyzed before after PICC insertion. predictive for LEDVT also evaluated. Results Univariate logistic regression analysis showed that insertion increased risk 9 times promoted increase 5 times. After adjustment, multivariate 4 tripled increase. concentration significantly unsuitable excluding PICCs. Conclusions increases level LEDVT. risks need be assessed ensure expected clinical outcomes.